Effects of the Antimicrobial Peptide LL-37 and Innate Effector Mechanisms in Colistin-Resistant Klebsiella pneumoniae With mgrB Insertions

BACKGROUND: Colistin is a polypeptide antibiotic drug that targets lipopolysaccharides in the outer membrane of Gram-negative bacteria. Inactivation of the mgrB-gene is a common mechanism behind colistin-resistance in Klebsiella pneumoniae (Kpn). Since colistin is a cyclic polypeptide, it may exhibi...

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Bibliografske podrobnosti
izdano v:Front Microbiol
Main Authors: Al-Farsi, Hissa M., Al-Adwani, Salma, Ahmed, Sultan, Vogt, Carmen, Ambikan, Anoop T., Leber, Anna, Al-Jardani, Amina, Al-Azri, Saleh, Al-Muharmi, Zakariya, Toprak, Muhammet S., Giske, Christian G., Bergman, Peter
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2019
Teme:
Microbiology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6870453/
https://ncbi.nlm.nih.gov/pubmed/31803163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2019.02632
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