MgrB-Dependent Colistin Resistance in Klebsiella pneumoniae Is Associated with an Increase in Host-to-Host Transmission

ABSTRACT Due to its high transmissibility, Klebsiella pneumoniae is one of the leading causes of nosocomial infections. Here, we studied the biological cost of colistin resistance, an antibiotic of last resort, in this opportunistic pathogen using a murine model of gut colonization and transmission....

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Main Authors: Andrew S. Bray, Richard D. Smith, Andrew W. Hudson, Giovanna E. Hernandez, Taylor M. Young, Hannah E. George, Robert K. Ernst, M. Ammar Zafar
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2022-04-01
Series:mBio
Assuntos:
antimicrobial peptides
gastrointestinal infection
host-to-host transmission
infection control
stress adaptation
two-component regulatory systems
Acceso en liña:https://journals.asm.org/doi/10.1128/mbio.03595-21
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