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Secondhand smoke exposure causes bronchial hyperreactivity via transcriptionally upregulated endothelin and 5-hydroxytryptamine 2A receptors.

BACKGROUND: Cigarette smoke exposure is strongly associated with airway hyperreactivity (AHR) which is the main characteristic seen in asthma. The intracellular MAPK signaling pathways are suggested to be associated with the airway damage to the AHR. In the present study, we hypothesize that secondh...

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Main Authors: Lei Cao, Yaping Zhang, Yong-Xiao Cao, Lars Edvinsson, Cang-Bao Xu
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science (PLoS) 2012-01-01
Serija:PLoS ONE
Online dostop:http://europepmc.org/articles/PMC3428315?pdf=render
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