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Signaling in fibrosis: TGF-β, WNT, and YAP/TAZ converge

Chronic organ injury leads to fibrosis and eventually organ failure. Fibrosis is characterized by excessive synthesis, remodeling and contraction of extracellular matrix produced by myofibroblasts. Myofibroblasts are the key cells in the pathophysiology of fibrotic disorders and their differentiatio...

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Sonraí Bibleagrafaíochta
Main Authors: Bram ePiersma, Ruud A Bank, Miriam eBoersema
Formáid: Artigo
Teanga:Inglês
Foilsithe: Frontiers Media S.A. 2015-09-01
Sraith:Frontiers in Medicine
Ábhair:
Wnt
Rochtain Ar Líne:http://journal.frontiersin.org/Journal/10.3389/fmed.2015.00059/full
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