Signaling in fibrosis: TGF-β, WNT, and YAP/TAZ converge

Chronic organ injury leads to fibrosis and eventually organ failure. Fibrosis is characterized by excessive synthesis, remodeling and contraction of extracellular matrix produced by myofibroblasts. Myofibroblasts are the key cells in the pathophysiology of fibrotic disorders and their differentiatio...

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Bibliographic Details
Main Authors: Bram ePiersma, Ruud A Bank, Miriam eBoersema
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2015-09-01
Series:Frontiers in Medicine
Subjects:
Fibrosis
Wnt
Hippo
myofibroblast
signal integration
TGF-β
Online Access:http://journal.frontiersin.org/Journal/10.3389/fmed.2015.00059/full
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