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Signaling in fibrosis: TGF-β, WNT, and YAP/TAZ converge

Chronic organ injury leads to fibrosis and eventually organ failure. Fibrosis is characterized by excessive synthesis, remodeling and contraction of extracellular matrix produced by myofibroblasts. Myofibroblasts are the key cells in the pathophysiology of fibrotic disorders and their differentiatio...

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Bibliografski detalji
Glavni autori: Bram ePiersma, Ruud A Bank, Miriam eBoersema
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2015-09-01
Serija:Frontiers in Medicine
Teme:
Wnt
Online pristup:http://journal.frontiersin.org/Journal/10.3389/fmed.2015.00059/full
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