Mycobacterium tuberculosis DosS binds H2S through its Fe3+ heme iron to regulate the DosR dormancy regulon

Mycobacterium tuberculosis (Mtb) senses and responds to host-derived gasotransmitters NO and CO via heme-containing sensor kinases DosS and DosT and the response regulator DosR. Hydrogen sulfide (H2S) is an important signaling molecule in mammals, but its role in Mtb physiology is unclear. We have p...

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Main Authors: Ritesh R. Sevalkar, Joel N. Glasgow, Martín Pettinati, Marcelo A. Marti, Vineel P. Reddy, Swati Basu, Elmira Alipour, Daniel B. Kim-Shapiro, Dario A. Estrin, Jack R. Lancaster, Jr., Adrie J.C. Steyn
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2022-06-01
Colecção:Redox Biology
Assuntos:
Hydrogen sulfide
Tuberculosis
Dormancy regulon
Two-component system
DosS
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S221323172200088X
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