Subdominant/cryptic CD8 T cell epitopes contribute to resistance against experimental infection with a human protozoan parasite.

During adaptive immune response, pathogen-specific CD8(+) T cells recognize preferentially a small number of epitopes, a phenomenon known as immunodominance. Its biological implications during natural or vaccine-induced immune responses are still unclear. Earlier, we have shown that during experimen...

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Main Authors: Mariana R Dominguez, Eduardo L V Silveira, José Ronnie C de Vasconcelos, Bruna C G de Alencar, Alexandre V Machado, Oscar Bruna-Romero, Ricardo T Gazzinelli, Mauricio M Rodrigues
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science (PLoS) 2011-01-01
Colecção:PLoS ONE
Acesso em linha:http://europepmc.org/articles/PMC3136500?pdf=render
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