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Case study: Targeted RNA-sequencing of aged formalin-fixed paraffin-embedded samples for understanding chemical mode of action

Formalin-fixed paraffin-embedded (FFPE) samples are the only remaining biological archive for many toxicological and clinical studies, yet their use in genomics has been limited due to nucleic acid damage from formalin fixation. Older FFPE samples with highly degraded RNA pose a particularly difficu...

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Main Authors: Michael D. Cannizzo, Charles E. Wood, Susan D. Hester, Leah C. Wehmas
格式: Artigo
語言:Inglês
出版: Elsevier 2022-01-01
叢編:Toxicology Reports
主題:
DCA
在線閱讀:http://www.sciencedirect.com/science/article/pii/S2214750022000956
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