mTOR and STAT3 Pathway Hyper-Activation is Associated with evated Interleukin-6 Levels in Patients with Shwachman-Diamond Syndrome: Further Evidence of Lymphoid Lineage Impairment

Shwachman–Diamond syndrome (SDS) is a rare inherited bone marrow failure syndrome, resulting in neutropenia and a risk of myeloid neoplasia. A mutation in a ribosome maturation factor accounts for almost all of the cases. Lymphoid involvement in SDS has not been well characterized. We recently repor...

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Bibliografski detalji
Glavni autori: Antonio Vella, Elisabetta D’Aversa, Martina Api, Giulia Breveglieri, Marisole Allegri, Alice Giacomazzi, Elena Marinelli Busilacchi, Benedetta Fabrizzi, Tiziana Cestari, Claudio Sorio, Gloria Bedini, Giovanna D’Amico, Vincenzo Bronte, Antonella Poloni, Antonio Benedetti, Chiara Bovo, Seth J. Corey, Monica Borgatti, Marco Cipolli, Valentino Bezzerri
Format: Artigo
Jezik:Inglês
Izdano: MDPI AG 2020-03-01
Serija:Cancers
Teme:
stat3
mtor
bone marrow failure syndromes
lymphocytes
Online pristup:https://www.mdpi.com/2072-6694/12/3/597
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