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Discovering thiamine transporters as targets of chloroquine using a novel functional genomics strategy.

Chloroquine (CQ) and other quinoline-containing antimalarials are important drugs with many therapeutic benefits as well as adverse effects. However, the molecular targets underlying most such effects are largely unknown. By taking a novel functional genomics strategy, which employs a unique combina...

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Detalhes bibliográficos
Main Authors: Zhiwei Huang, Sankaranarayanan Srinivasan, Jianhuai Zhang, Kaifu Chen, Yongxiang Li, Wei Li, Florante A Quiocho, Xuewen Pan
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science (PLoS) 2012-01-01
Colecção:PLoS Genetics
Acesso em linha:http://europepmc.org/articles/PMC3510038?pdf=render
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