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Amino acid response by Halofuginone in Cancer cells triggers autophagy through proteasome degradation of mTOR
Abstract Background In the event of amino acid starvation, the cell activates two main protective pathways: Amino Acid starvation Response (AAR), to inhibit global translation, and autophagy, to recover the essential substrates from degradation of redundant self-components. Whether and how AAR and a...
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| Главные авторы: | , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
BMC
2019-05-01
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| Серии: | Cell Communication and Signaling |
| Предметы: | |
| Online-ссылка: | http://link.springer.com/article/10.1186/s12964-019-0354-2 |
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