Amino acid response by Halofuginone in Cancer cells triggers autophagy through proteasome degradation of mTOR

Abstract Background In the event of amino acid starvation, the cell activates two main protective pathways: Amino Acid starvation Response (AAR), to inhibit global translation, and autophagy, to recover the essential substrates from degradation of redundant self-components. Whether and how AAR and a...

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Main Authors: Carlo Follo, Chiara Vidoni, Federica Morani, Alessandra Ferraresi, Christian Seca, Ciro Isidoro
Formato: Artigo
Idioma:Inglês
Publicado: BMC 2019-05-01
Series:Cell Communication and Signaling
Assuntos:
Autophagy
Starvation
mTORC1
Lysosome
TFEB
Protein translation
Acceso en liña:http://link.springer.com/article/10.1186/s12964-019-0354-2
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