Amino acid response by Halofuginone in Cancer cells triggers autophagy through proteasome degradation of mTOR

Abstract Background In the event of amino acid starvation, the cell activates two main protective pathways: Amino Acid starvation Response (AAR), to inhibit global translation, and autophagy, to recover the essential substrates from degradation of redundant self-components. Whether and how AAR and a...

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Bibliografiske detaljer
Main Authors: Carlo Follo, Chiara Vidoni, Federica Morani, Alessandra Ferraresi, Christian Seca, Ciro Isidoro
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2019-05-01
Serier:Cell Communication and Signaling
Fag:
Autophagy
Starvation
mTORC1
Lysosome
TFEB
Protein translation
Online adgang:http://link.springer.com/article/10.1186/s12964-019-0354-2
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