The redox function of APE1 is involved in the differentiation process of stem cells toward a neuronal cell fate.

Low-to-moderate levels of reactive oxygen species (ROS) govern different steps of neurogenesis via molecular pathways that have been decrypted only partially. Although it has been postulated that redox-sensitive molecules are involved in neuronal differentiation, the molecular bases for this process...

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Main Authors: Rossana Domenis, Natascha Bergamin, Giuseppe Gianfranceschi, Carlo Vascotto, Milena Romanello, Silvia Rigo, Giovanna Vagnarelli, Massimo Faggiani, Piercamillo Parodi, Mark R Kelley, Carlo Alberto Beltrami, Daniela Cesselli, Gianluca Tell, Antonio Paolo Beltrami
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science (PLoS) 2014-01-01
Colecção:PLoS ONE
Acesso em linha:http://europepmc.org/articles/PMC3929656?pdf=render
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