[Pt(O,O'-acac)(γ-acac)(DMS)] alters SH-SY5Y cell migration and invasion by the inhibition of Na+/H+ exchanger isoform 1 occurring through a PKC-ε/ERK/mTOR Pathway.

We previously showed that [Pt(O,O'-acac)(γ-acac)(DMS)] ([Pt(acac)2(DMS)]) exerted substantial cytotoxic effects in SH-SY5Y neuroblastoma cells, and decreased metalloproteases (MMPs) production and cells migration in MCF-7 breast cancer cells. The ubiquitously distributed sodium-hydrogen antipor...

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Bibliografiska uppgifter
Huvudupphovsmän: Antonella Muscella, Carla Vetrugno, Nadia Calabriso, Luca Giulio Cossa, Sandra Angelica De Pascali, Francesco Paolo Fanizzi, Santo Marsigliante
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science (PLoS) 2014-01-01
Serie:PLoS ONE
Länkar:http://europepmc.org/articles/PMC4221608?pdf=render
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