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Interference of retroviral envelope with vaccine-induced CD8+ T cell responses is relieved by co-administration of cytokine-encoding vectors

Abstract Background Retroviral envelope (Env) proteins are known to exhibit immunosuppressive properties, which become apparent not only in retroviral infections, but also in gene-based immunizations using retroviral immunogens, where envelope interferes with the induction of CD8+ T cell responses t...

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Main Authors: Nadine Bongard, Dennis Lapuente, Sonja Windmann, Ulf Dittmer, Matthias Tenbusch, Wibke Bayer
格式: Artigo
語言:Inglês
出版: BMC 2017-04-01
叢編:Retrovirology
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在線閱讀:http://link.springer.com/article/10.1186/s12977-017-0352-7
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