Why Is a High Temperature Needed by Thermus thermophilus Argonaute During mRNA Silencing: A Theoretical Study

Thermus thermophiles Argonaute (TtAgo) is a complex, which is consisted of 5′-phosphorylated guide DNA and a series of target DNA with catalytic activities at high temperatures. To understand why high temperatures are needed for the catalytic activities, three molecular dynamics simulations and bind...

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Main Authors: Ye Liu, Zhengfei Yu, Jingxuan Zhu, Song Wang, Dong Xu, Weiwei Han
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018-06-01
Colecção:Frontiers in Chemistry
Assuntos:
Thermus thermophilus Argonaute
gene editing
CRISPR
molecular dynamics simulation
MM-PBSA
conformational change
Acesso em linha:https://www.frontiersin.org/article/10.3389/fchem.2018.00223/full
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