Do changes in DNA methylation mediate or interact with SNP variation? A pharmacoepigenetic analysis

Abstract Background In studies with multi-omics data available, there is an opportunity to investigate interdependent mechanisms of biological causality. The GAW20 data set includes both DNA genotype and methylation measures before and after fenofibrate treatment. Using change in triglyceride (TG) l...

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Hlavní autoři: Virginia A. Fisher, Lan Wang, Xuan Deng, Chloé Sarnowski, L. Adrienne Cupples, Ching-Ti Liu
Médium: Artigo
Jazyk:Inglês
Vydáno: BMC 2018-09-01
Edice:BMC Genetics
Témata:
Causal modeling
Genomic data integration
Gene-methylation interaction
Indirect effects
Triglycerides
Genofibrate treatment
On-line přístup:http://link.springer.com/article/10.1186/s12863-018-0635-6
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