An Inhibitor of the Sodium–Hydrogen Exchanger-1 (NHE-1), Amiloride, Reduced Zinc Accumulation and Hippocampal Neuronal Death after Ischemia

Acidosis in the brain plays an important role in neuronal injury and is a common feature of several neurological diseases. It has been reported that the sodium–hydrogen exchanger-1 (NHE-1) is a key mediator of acidosis-induced neuronal injury. It modulates the concentration of intra- and extra-cellu...

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Hlavní autoři: Beom Seok Kang, Bo Young Choi, A Ra Kho, Song Hee Lee, Dae Ki Hong, Jeong Hyun Jeong, Dong Hyeon Kang, Min Kyu Park, Sang Won Suh
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI AG 2020-06-01
Edice:International Journal of Molecular Sciences
Témata:
global cerebral ischemia
amiloride
sodium–hydrogen exchanger-1
zinc
neuronal death
neuroprotection
On-line přístup:https://www.mdpi.com/1422-0067/21/12/4232
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