Сandidate SNP-markers of rheumatoid arthritis that can significantly alter the affinity of the TATA-binding protein for human gene promoters

Rheumatoid polyarthritis (RA) is an autoimmune disease with autoantibodies, including antibodies to citrullant antigens and proinflammatory cytokines, such as TNF-α and IL-6, which are involved in the induction of chronic synovitis, bone erosion, followed by deformity. Immunopathogenesis is based on...

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Main Authors: I. V. Chadaeva, D. A. Rasskazov, E. B. Sharypova, I. A. Drachkova, E. A. Oshchepkova, L. K. Savinkova, P. M. Ponomarenko, M. P. Ponomarenko, N. A. Kolchanov, V. A. Kozlov
Format: Artigo
Sprog:Inglês
Udgivet: Institute of Cytology and Genetics of Siberian Branch of the Russian Academy of Sciences 2020-01-01
Serier:Vavilovskij Žurnal Genetiki i Selekcii
Fag:
tata binding protein (tbp)
tbp-binding site (tata box)
promoter
tbp-promoter affinity
gene
single nucleotide polymorphism (snp)
gene expression
significant change
snp-marker
rheumatoid polyarthritis (ra)
Online adgang:https://vavilov.elpub.ru/jour/article/view/2398
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