The involvement of tau in nucleolar transcription and the stress response

Abstract Tau is known for its pathological role in neurodegenerative diseases, including Alzheimer’s disease (AD) and other tauopathies. Tau is found in many subcellular compartments such as the cytosol and the nucleus. Although its normal role in microtubule binding is well established, its nuclear...

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Bibliographic Details
Main Authors: Mahmoud B. Maina, Laura J. Bailey, Sherin Wagih, Luca Biasetti, Saskia J. Pollack, James P. Quinn, Julian R. Thorpe, Aidan J. Doherty, Louise C. Serpell
Format: Artigo
Language:Inglês
Published: BMC 2018-07-01
Series:Acta Neuropathologica Communications
Subjects:
Tau
Nucleolus, Nucleolar stress, rDNA
Transcription
Tauopathy
Alzheimer’s disease
Online Access:http://link.springer.com/article/10.1186/s40478-018-0565-6
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