The Anti-neuroinflammatory Activity of Tectorigenin Pretreatment via Downregulated NF-κB and ERK/JNK Pathways in BV-2 Microglial and Microglia Inactivation in Mice With Lipopolysaccharide

The activation of microglia is decisively involved with the neurodegeneration observed in many neuroinflammatory pathologies, such as multiple sclerosis, Parkinson’s disease, and Alzheimer’s disease. Tectorigenin (TEC) is an isoflavone isolated from various medicinal plants, such as Pueraria thunber...

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Bibliografiske detaljer
Main Authors: Hye-Sun Lim, Yu Jin Kim, Bu-Yeo Kim, Gunhyuk Park, Soo-Jin Jeong
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2018-05-01
Serier:Frontiers in Pharmacology
Fag:
tectorigenin
neuroinflammation
microglia
mitogen-activated protein kinases
nuclear factor-κB
Online adgang:http://journal.frontiersin.org/article/10.3389/fphar.2018.00462/full
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