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Differential Regulation of Cardiac Function and Intracardiac Cytokines by Rapamycin in Healthy and Diabetic Rats

Diabetes is comorbid with cardiovascular disease and impaired immunity. Rapamycin improves cardiac functions and extends lifespan by inhibiting the mechanistic target of rapamycin complex 1 (mTORC1). However, in diabetic murine models, Rapamycin elevates hyperglycemia and reduces longevity. Since Ra...

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書誌詳細
主要な著者: Christian Luck, Vincent G. DeMarco, Abuzar Mahmood, Madhavi P. Gavini, Lakshmi Pulakat
フォーマット: Artigo
言語:Inglês
出版事項: Hindawi Limited 2017-01-01
シリーズ:Oxidative Medicine and Cellular Longevity
オンライン・アクセス:http://dx.doi.org/10.1155/2017/5724046
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