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Differential Regulation of Cardiac Function and Intracardiac Cytokines by Rapamycin in Healthy and Diabetic Rats

Diabetes is comorbid with cardiovascular disease and impaired immunity. Rapamycin improves cardiac functions and extends lifespan by inhibiting the mechanistic target of rapamycin complex 1 (mTORC1). However, in diabetic murine models, Rapamycin elevates hyperglycemia and reduces longevity. Since Ra...

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Main Authors: Christian Luck, Vincent G. DeMarco, Abuzar Mahmood, Madhavi P. Gavini, Lakshmi Pulakat
Formato: Artigo
Idioma:Inglês
Publicado: Hindawi Limited 2017-01-01
Series:Oxidative Medicine and Cellular Longevity
Acceso en liña:http://dx.doi.org/10.1155/2017/5724046
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