APOE ε4 genotype-dependent cerebrospinal fluid proteomic signatures in Alzheimer’s disease

Abstract Background Aggregation of amyloid β into plaques in the brain is one of the earliest pathological events in Alzheimer’s disease (AD). The exact pathophysiology leading to dementia is still uncertain, but the apolipoprotein E (APOE) ε4 genotype plays a major role. We aimed to identify the mo...

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Detaylı Bibliyografya
Asıl Yazarlar: Elles Konijnenberg, Betty M. Tijms, Johan Gobom, Valerija Dobricic, Isabelle Bos, Stephanie Vos, Magda Tsolaki, Frans Verhey, Julius Popp, Pablo Martinez-Lage, Rik Vandenberghe, Alberto Lleó, Lutz Frölich, Simon Lovestone, Johannes Streffer, Lars Bertram, Kaj Blennow, Charlotte E. Teunissen, Robert Veerhuis, August B. Smit, Philip Scheltens, Henrik Zetterberg, Pieter Jelle Visser
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BMC 2020-05-01
Seri Bilgileri:Alzheimer’s Research & Therapy
Konular:
Amyloid aggregation
APOE genotype
CSF proteomics
Online Erişim:http://link.springer.com/article/10.1186/s13195-020-00628-z
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