Synthesis of (2S,4S)-N-tert-butoxycarbonyl-4-fluoroproline

In order to overcome the difficulty to separate and purify the intermediate, solve the problem of quaternary ammonium salt removal,the synthesis of (2S,4S)-N-tert-butoxycarbonyl-4-fluoroproline which is a key intermediate of polypeptides and peptidomimetic drug is studied. The target compound is syn...

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Main Authors: Tiantian LIU, Zhiguang ZHANG, Yuanyuan YANG, Yantao MA, Yong ZHANG
Formato: Artigo
Idioma:Chinês
Publicado em: Hebei University of Science and Technology 2018-04-01
Colecção:Journal of Hebei University of Science and Technology
Assuntos:
organic synthesis chemistry
unnatural amino acids
intermediates
tandem reaction
SN2 reaction
Acesso em linha:http://xuebao.hebust.edu.cn/hbkjdx/ch/reader/create_pdf.aspx?file_no=b201802009&flag=1&journal_
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