Small Molecule Inhibitor Targeting CDT1/Geminin Protein Complex Promotes DNA Damage and Cell Death in Cancer Cells

DNA replication initiation requires the loading of MCM2-7 complexes at the origins of replication during G1. Replication licensing renders chromatin competent for DNA replication and its tight regulation is essential to prevent aberrant DNA replication and genomic instability. CDT1 is a critical fac...

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Main Authors: Nikolaos Karantzelis, Michalis Petropoulos, Valeria De Marco, David A. Egan, Alexander Fish, Evangelos Christodoulou, David W. Will, Joe D. Lewis, Anastassis Perrakis, Zoi Lygerou, Stavros Taraviras
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2022-04-01
Serier:Frontiers in Pharmacology
Fag:
AlphaScreen
small molecule inhibitor
high-throughput screening
Geminin
CDT1
cancer
Online adgang:https://www.frontiersin.org/articles/10.3389/fphar.2022.860682/full
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