Effect of neoadjuvant chemotherapy on the immune microenvironment in non–small cell lung carcinomas as determined by multiplex immunofluorescence and image analysis approaches

Abstract Background The clinical efficacy observed with inhibitors of programed cell death 1/programed cell death ligand 1 (PD-L1/PD-1) in cancer therapy has prompted studies to characterize the immune response in several tumor types, including lung cancer. However, the immunological profile of non–...

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Detalhes bibliográficos
Main Authors: Edwin R. Parra, Pamela Villalobos, Carmen Behrens, Mei Jiang, Apar Pataer, Stephen G. Swisher, William N. William, Jiexin Zhang, Jack Lee, Tina Cascone, John V. Heymach, Marie-Andrée Forget, Cara Haymaker, Chantale Bernatchez, Neda Kalhor, Annikka Weissferdt, Cesar Moran, Jianjun Zhang, Ara Vaporciyan, Don L. Gibbons, Boris Sepesi, Ignacio I. Wistuba
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2018-06-01
Colecção:Journal for ImmunoTherapy of Cancer
Assuntos:
Tumor compartments
Epithelial compartment
Stromal compartment
Adenocarcinoma
Squamous cell carcinoma
Survival
Acesso em linha:http://link.springer.com/article/10.1186/s40425-018-0368-0
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