The CSF Vancomycin Concentration in Patients With Post-operative Intracranial Infection Can Be Predicted by the WBCs to Total Cells Ratio and the Serum Trough Concentration

BackgroundThe pharmacokinetics of vancomycin in cerebrospinal fluid (CSF) is an important basis for evaluating the bactericidal effect. The accuracy of using serum vancomycin concentrations only to estimate the CSF concentrations remains controversial, may lead to underdosing.ObjectivesThe aims of t...

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Main Authors: Ming-Chao Fan, Jia-Lin Sun, Jian Sun, Jun-Wei Ma, Nian Wang, Wei Fang
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2022-05-01
Colecção:Frontiers in Neurology
Assuntos:
vancomycin
intracranial infection
blood-brain barrier
cerebrospinal fluid
serum trough concentration
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fneur.2022.893089/full
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