Quantitative Imaging of White and Gray Matter Remyelination in the Cuprizone Demyelination Model Using the Macromolecular Proton Fraction

Macromolecular proton fraction (MPF) has been established as a quantitative clinically-targeted MRI myelin biomarker based on recent demyelination studies. This study aimed to assess the capability of MPF to quantify remyelination using the murine cuprizone-induced reversible demyelination model. MP...

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Autors principals: Marina Khodanovich, Anna Pishchelko, Valentina Glazacheva, Edgar Pan, Andrey Akulov, Mikhail Svetlik, Yana Tyumentseva, Tatyana Anan’ina, Vasily Yarnykh
Format: Artigo
Idioma:Inglês
Publicat: MDPI AG 2019-10-01
Col·lecció:Cells
Matèries:
macromolecular proton fraction
mpf
myelin
magnetic resonance imaging
cuprizone model
demyelination
remyelination
oligodendrocyte precursors
oligodendrocytes
immunohistochemistry
Accés en línia:https://www.mdpi.com/2073-4409/8/10/1204
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