Slowly expanding lesions relate to persisting black-holes and clinical outcomes in relapse-onset multiple sclerosis

Background: Slowly expanding lesions (SELs) are MRI markers of chronic active lesions in multiple sclerosis (MS). T1-hypointense black holes, and reductions in magnetization transfer ratio (MTR) are pathologically correlated with myelin and axonal loss. While all associated with progressive MS, the...

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Detalhes bibliográficos
Main Authors: Alberto Calvi, Carmen Tur, Declan Chard, Jonathan Stutters, Olga Ciccarelli, Rosa Cortese, Marco Battaglini, Anna Pietroboni, Milena De Riz, Daniela Galimberti, Elio Scarpini, Nicola De Stefano, Ferran Prados, Frederik Barkhof
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2022-01-01
Colecção:NeuroImage: Clinical
Assuntos:
Chronic active lesions
SEL
Black holes
Volumetric MRI
Multiple sclerosis
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2213158222001139
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