Process optimization for enhancing production of cis-4-hydroxy-l-proline by engineered Escherichia coli

Abstract Background Understanding the bioprocess limitations is critical for the efficient design of biocatalysts to facilitate process feasibility and improve process economics. In this study, a proline hydroxylation process with recombinant Escherichia coli expressing l-proline cis-4-hydroxylase (...

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Bibliographic Details
Main Authors: Kequan Chen, Yang Pang, Bowen Zhang, Jiao Feng, Sheng Xu, Xin Wang, Pingkai Ouyang
Format: Artigo
Language:Inglês
Published: BMC 2017-11-01
Series:Microbial Cell Factories
Subjects:
cis-4-Hydroxy-l-proline
Process limitations
Two-strain coupling system
Online Access:http://link.springer.com/article/10.1186/s12934-017-0821-7
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