Endothelial damage and a thin intercellular fibrin network promote haemorrhage in acute promyelocytic leukaemia

Background: The role of vascular endothelium in acute promyelocytic leukaemia (APL) remains unknown. We aimed to investigate the mechanisms by which APL cells interact with endothelial cells (ECs) and to further explore how the endothelium affects bleeding as well as therapeutic interventions. Metho...

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Bibliografski detalji
Glavni autori: Chunxu Wang, Muxin Yu, Peng Zhou, Baorong Li, Yingmiao Liu, Lixiu Wang, Xiaojing Chen, Jingwen Du, Yufeng Wang, Jinming Zhang, Haijiao Jing, Yiming Feng, Yue Zhang, Yueyue Li, Zengxiang Dong, Shaohong Fang, Valerie A Novakovic, Jin Zhou, Jialan Shi
Format: Artigo
Jezik:Inglês
Izdano: Elsevier 2020-10-01
Serija:EBioMedicine
Teme:
Acute promyelocytic leukaemia
Endothelial cells
Permeability
Fibrin
Haemorrhage
Online pristup:http://www.sciencedirect.com/science/article/pii/S2352396420303686
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