Oxidized lipids activate autophagy in a JNK-dependent manner by stimulating the endoplasmic reticulum stress response

Excessive production of unsaturated aldehydes from oxidized lipoproteins and membrane lipids is a characteristic feature of cardiovascular disease. Our previous studies show that unsaturated lipid peroxidation-derived aldehydes such as 4-hydroxy-trans-2-nonenal (HNE) promote autophagy in rat aortic...

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Hauptverfasser: Petra Haberzettl, Bradford G. Hill
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2013-01-01
Schriftenreihe:Redox Biology
Schlagworte:
Oxidative stress
Autophagy
4-hydroxynonenal
JNK
Unfolded protein response
Smooth muscle cells
Online Zugang:http://www.sciencedirect.com/science/article/pii/S2213231712000134
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