Phenotypic and molecular states of IDH1 mutation-induced CD24-positive glioma stem-like cells

Mutations in IDH1 and IDH2 drive the development of gliomas. These genetic alterations promote tumor cell renewal, disrupt differentiation states, and induce stem-like properties. Understanding how this phenotypic reprogramming occurs remains an area of high interest in glioma research. Previously,...

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Bibliographic Details
Main Authors: Sara Haddock, Tyler J. Alban, Şevin Turcan, Hana Husic, Eric Rosiek, Xiaoxiao Ma, Yuxiang Wang, Tejus Bale, Alexis Desrichard, Vladimir Makarov, Sebastien Monette, Wei Wu, Rui Gardner, Katia Manova, Adrienne Boire, Timothy A. Chan
Format: Artigo
Language:Inglês
Published: Elsevier 2022-06-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
IDH1 mutation
Low-grade glioma
CD24
cancer stem cells
Neural stem cells
Orthotopic mouse model
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558622000197
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