An obesogenic feedforward loop involving PPARγ, acyl-CoA binding protein and GABAA receptor

Abstract Acyl-coenzyme-A-binding protein (ACBP), also known as a diazepam-binding inhibitor (DBI), is a potent stimulator of appetite and lipogenesis. Bioinformatic analyses combined with systematic screens revealed that peroxisome proliferator-activated receptor gamma (PPARγ) is the transcription f...

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Detalhes bibliográficos
Main Authors: Gerasimos Anagnostopoulos, Omar Motiño, Sijing Li, Vincent Carbonnier, Hui Chen, Valentina Sica, Sylvère Durand, Mélanie Bourgin, Fanny Aprahamian, Nitharsshini Nirmalathasan, Romain Donne, Chantal Desdouets, Marcelo Simon Sola, Konstantina Kotta, Léa Montégut, Flavia Lambertucci, Didier Surdez, Grossetête Sandrine, Olivier Delattre, Maria Chiara Maiuri, José Manuel Bravo-SanPedro, Isabelle Martins, Guido Kroemer
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2022-04-01
Colecção:Cell Death and Disease
Acesso em linha:https://doi.org/10.1038/s41419-022-04834-5
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