Circulating Pentraxin3-Specific B Cells Are Decreased in Lupus Nephritis

Background: Pentraxin3 (PTX3) is overexpressed in kidneys of patients developing lupus nephritis (LN). Active LN is associated with reduced anti-PTX3 antibodies. However, abnormalities of B cell differentiation against PTX3 have not been characterized in systemic lupus erythematosus (SLE).Objective:...

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Main Authors: Mariele Gatto, Annika Wiedemann, Nadja Nomovi, Karin Reiter, Eva Schrezenmeier, Thomas Rose, Franziska Szelinski, Andreia C. Lino, Sonia Valentino, Anna Ghirardello, Thomas Dörner, Andrea Doria
Formáid: Artigo
Teanga:Inglês
Foilsithe: Frontiers Media S.A. 2019-01-01
Sraith:Frontiers in Immunology
Ábhair:
SLE
PTX3+ B cells
lupus nephritis
biomarkers
flow-cytometry
Rochtain Ar Líne:https://www.frontiersin.org/article/10.3389/fimmu.2019.00029/full
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