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New insights into the Hendra virus attachment and entry process from structures of the virus G glycoprotein and its complex with Ephrin-B2.

Hendra virus and Nipah virus, comprising the genus Henipavirus, are recently emerged, highly pathogenic and often lethal zoonotic agents against which there are no approved therapeutics. Two surface glycoproteins, the attachment (G) and fusion (F), mediate host cell entry. The crystal structures of...

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Detalhes bibliográficos
Main Authors: Kai Xu, Yee-Peng Chan, Kanagalaghatta R Rajashankar, Dimple Khetawat, Lianying Yan, Momchil V Kolev, Christopher C Broder, Dimitar B Nikolov
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science (PLoS) 2012-01-01
Colecção:PLoS ONE
Acesso em linha:http://europepmc.org/articles/PMC3489827?pdf=render
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