Prenatal Administration of Betamethasone Causes Changes in the T Cell Receptor Repertoire Influencing Development of Autoimmunity

Prenatal glucocorticoids are routinely administered to pregnant women at risk of preterm delivery in order to improve survival of the newborn. However, in half of the cases, birth occurs outside the beneficial period for lung development. Glucocorticoids are potent immune modulators and cause apopto...

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Detalhes bibliográficos
Main Authors: Anna Gieras, Christina Gehbauer, David Perna-Barrull, Jan Broder Engler, Ines Diepenbruck, Laura Glau, Simon A. Joosse, Nora Kersten, Stefanie Klinge, Hans-Willi Mittrücker, Manuel A. Friese, Marta Vives-Pi, Eva Tolosa
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017-11-01
Colecção:Frontiers in Immunology
Assuntos:
glucocorticoids
prenatal betamethasone
T cell repertoire
autoimmunity
type 1 diabetes
non-obese diabetic mice
Acesso em linha:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01505/full
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