Synergistic effect of IL-12 and IL-18 induces TIM3 regulation of γδ T cell function and decreases the risk of clinical malaria in children living in Papua New Guinea

Abstract Background γδ T cells are important for both protective immunity and immunopathogenesis during malaria infection. However, the immunological processes determining beneficial or detrimental effects on disease outcome remain elusive. The aim of this study was to examine expression and regulat...

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Hauptverfasser: Louis Schofield, Lisa J. Ioannidis, Stephan Karl, Leanne J. Robinson, Qiao Y. Tan, Daniel P. Poole, Inoni Betuela, Danika L. Hill, Peter M. Siba, Diana S. Hansen, Ivo Mueller, Emily M. Eriksson
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMC 2017-06-01
Schriftenreihe:BMC Medicine
Schlagworte:
γδ T cells
TIM3
IL-12
IL-18
Malaria
Plasmodium
Online Zugang:http://link.springer.com/article/10.1186/s12916-017-0883-8
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