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Synergistic effect of IL-12 and IL-18 induces TIM3 regulation of γδ T cell function and decreases the risk of clinical malaria in children living in Papua New Guinea

BACKGROUND: γδ T cells are important for both protective immunity and immunopathogenesis during malaria infection. However, the immunological processes determining beneficial or detrimental effects on disease outcome remain elusive. The aim of this study was to examine expression and regulatory effe...

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Detalhes bibliográficos
Publicado no:BMC Med
Main Authors: Schofield, Louis, Ioannidis, Lisa J., Karl, Stephan, Robinson, Leanne J., Tan, Qiao Y., Poole, Daniel P., Betuela, Inoni, Hill, Danika L., Siba, Peter M., Hansen, Diana S., Mueller, Ivo, Eriksson, Emily M.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5471992/
https://ncbi.nlm.nih.gov/pubmed/28615061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12916-017-0883-8
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