Guanabenz Prevents d-Galactosamine/Lipopolysaccharide-Induced Liver Damage and Mortality

Multi-organ failure in response to uncontrolled microbial infection is characterized by low blood pressure accompanied by a systemic over-inflammation state, caused by massive pro-inflammatory cytokines release and liver damage. Recently, the integrated stress response (ISR), characterized by eukary...

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Huvudupphovsmän: Jessica Perego, Clarisse Bourbon, Lionel Chasson, Caroline Laprie, Lionel Spinelli, Voahirana Camosseto, Evelina Gatti, Philippe Pierre
Materialtyp: Artigo
Språk:Inglês
Publicerad: Frontiers Media S.A. 2017-06-01
Serie:Frontiers in Immunology
Ämnen:
guanabenz
lipopolysaccharide-induced liver damage
TLR4
unfolded protein response
Ppp1r15a
Länkar:http://journal.frontiersin.org/article/10.3389/fimmu.2017.00679/full
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