Alternative dosing of dual PI3K and MEK inhibition in cancer therapy

<p>Abstract</p> <p>Background</p> <p>PI3K/AKT/mTOR and RAS/RAF/MEK/ERK pathways are thought to be the central transducers of oncogenic signals in solid malignancies, and there has been a lot of enthusiasm for developing inhibitors of these pathways for cancer therapy. S...

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Bibliographic Details
Main Authors: Jokinen Elina, Laurila Niina, Koivunen Jussi P
Format: Artigo
Language:Inglês
Published: BMC 2012-12-01
Series:BMC Cancer
Subjects:
Non-small cell lung cancer
PI3K inhibition
MEK inhibition
Online Access:http://www.biomedcentral.com/1471-2407/12/612
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