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Vaccinia virus E3 protein prevents the antiviral action of ISG15.
The ubiquitin-like modifier ISG15 is one of the most predominant proteins induced by type I interferons (IFN). In this study, murine embryo fibroblast (MEFs) and mice lacking the gene were used to demonstrate a novel role of ISG15 as a host defense molecule against vaccinia virus (VACV) infection. I...
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| Auteurs principaux: | , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Public Library of Science (PLoS)
2008-07-01
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| Collection: | PLoS Pathogens |
| Accès en ligne: | http://europepmc.org/articles/PMC2434199?pdf=render |
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