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Vaccinia virus E3 protein prevents the antiviral action of ISG15.

The ubiquitin-like modifier ISG15 is one of the most predominant proteins induced by type I interferons (IFN). In this study, murine embryo fibroblast (MEFs) and mice lacking the gene were used to demonstrate a novel role of ISG15 as a host defense molecule against vaccinia virus (VACV) infection. I...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Susana Guerra, Ana Cáceres, Klaus-Peter Knobeloch, Ivan Horak, Mariano Esteban
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science (PLoS) 2008-07-01
Cyfres:PLoS Pathogens
Mynediad Ar-lein:http://europepmc.org/articles/PMC2434199?pdf=render
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