Novel Small Molecule Inhibitors Targeting the IL-6/STAT3 Pathway or IL-1β

Development of small molecules that inhibit inflammatory cytokines is a desirable strategy for the treatment of inflammatory diseases such as rheumatoid arthritis (RA). Following up a previous study, we synthesized 10 novel compounds with a 2,5-diaminobenzoxazole moiety and evaluated their biologica...

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Main Authors: Jihye Yoo, Darong Kim, Jiyoung Park, Young-Kook Kim, Hea-Young Park Choo, Hyun Ae Woo
Formato: Artigo
Idioma:Inglês
Publicado: MDPI AG 2022-04-01
Series:Molecules
Assuntos:
2,5-diaminnobenzoxazole
anti-inflammatory effect
rheumatoid arthritis
IL-6
IL-1β
zymosan A
Acceso en liña:https://www.mdpi.com/1420-3049/27/9/2696
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