Single-Cell Proteomics and Tumor RNAseq Identify Novel Pathways Associated With Clofazimine Sensitivity in PI- and IMiD- Resistant Myeloma, and Putative Stem-Like Cells

Multiple myeloma (MM) is an incurable plasma cell malignancy with dose-limiting toxicities and inter-individual variation in response/resistance to the standard-of-care/primary drugs, proteasome inhibitors (PIs), and immunomodulatory derivatives (IMiDs). Although newer therapeutic options are potent...

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Main Authors: Harish Kumar, Suman Mazumder, Neeraj Sharma, Sayak Chakravarti, Mark D. Long, Nathalie Meurice, Joachim Petit, Song Liu, Marta Chesi, Sabyasachi Sanyal, A. Keith Stewart, Shaji Kumar, Leif Bergsagel, S. Vincent Rajkumar, Linda B. Baughn, Brian G. Van Ness, Amit Kumar Mitra
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2022-05-01
Colecção:Frontiers in Oncology
Assuntos:
CyTOF
RNAseq
myeloma
clofazimine
proteasome inhibitors (PI)
immunomodulatory drugs (IMiDs)
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fonc.2022.842200/full
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