DNA Methylation Changes in Intron 1 of Triggering Receptor Expressed on Myeloid Cell 2 in Japanese Schizophrenia Subjects

A hypothesis for schizophrenia (SCZ) called the “microglia hypothesis” has been suggested. In SCZ, expression of triggering receptor expressed on myeloid cell 2 (TREM2) mRNA is higher in leukocytes than in healthy individuals. Here, the methylation rates of four CpG sites in TREM2 intron 1 that may...

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Bibliographic Details
Main Authors: Yuta Yoshino, Yuki Ozaki, Kiyohiro Yamazaki, Tomoko Sao, Yoko Mori, Shinichiro Ochi, Jun-ichi Iga, Shu-ichi Ueno
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2017-05-01
Series:Frontiers in Neuroscience
Subjects:
schizophrenia
triggering receptor expressed on myeloid cell 2
TREM2
methylation rate
mRNA expression
pyrosequencing
Online Access:http://journal.frontiersin.org/article/10.3389/fnins.2017.00275/full
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