Increased proteinase 3 and neutrophil elastase plasma concentrations are associated with non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes

Abstract Introduction Non-alcoholic fatty liver disease (NAFLD) is becoming a major health problem worldwide. Inflammation plays an important role in disease pathogenesis and recent studies have shown a potential role for the neutrophil serine proteases (NSPs) proteinase-3 (PR3) and neutrophil elast...

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Главные авторы: Andreea-Manuela Mirea, Erik J. M. Toonen, Inge van den Munckhof, Isabelle D. Munsterman, Eric T. T. L. Tjwa, Martin Jaeger, Marije Oosting, Kiki Schraa, Joost H. W. Rutten, Marinette van der Graaf, Niels P. Riksen, Jacqueline de Graaf, Mihai G. Netea, Cees J. Tack, Triantafyllos Chavakis, Leo A. B. Joosten
Формат: Artigo
Язык:Inglês
Опубликовано: BMC 2019-05-01
Серии:Molecular Medicine
Предметы:
Obesity
Inflammation
NAFLD
Type 2 diabetes
Neutrophil serine proteases
Alpha-1 antitrypsin
Online-ссылка:http://link.springer.com/article/10.1186/s10020-019-0084-3
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